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In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

• Sales Rank: #5717797 in Books
• Published on: 2016-09-06
• Original language: English
• Dimensions: 9.90" h x .70" w x 6.80" l, 1.42 pounds
• Binding: Hardcover
• 240 pages

About the Author
Volume Editors:

Gottfried Unden studied Biology and Chemistry at the Ludwig Maximilians University Munich where he received his Dr. rer. nat. Since 1993 he is Professor for Microbiology at the Department of Microbiology and Wine Research at the University of Mainz. The main areas of work is bacterial metabolism and its adaptation to changing environmental conditions like switching from aerobic to anaerobic metabolism, or the use of carboxylic acid as the substrate for growth, and the function of bacterial sensors.

Eckhard Thines studied Biology at the University of Kaiserslautern, Germany, where he received his PhD in Biotechnology. As a postdoctoral fellow he spent two years in Professor Nicholas Talbot's laboratory in Exeter, UK. He joined the Institute of Biotechnology and Drug Research (IBWF) in Kaiserslautern, Germany in 2006. Since 2009 he is CSO of the IBWF and since 2012 he is Professor for Biotechnology and Drug Research at the University of Mainz. His research focusses on fungicide research, mode of action research, target identification and validation as well as fungal secondary metabolism. Furthermore he is interested in host/pathogen-interactions in fungal plant diseases, e.g. Esca and grape black rot.

Anja Sch?ffler studied Biology at the University of Kaiserslautern. Her PhD focused on the characterisation of fungal natural products with antimicrobial activity. In 2010 she joined Professor William Fenical?s group at the Scripps Institute for Oceanography in San Diego, where she studied antibacterial natural products from streptomycetes. In 2011 she started a research fellowship at the Institute of Biotechnology and Drug Research (IBWF, Kaiserslautern). Her scientific work focuses on fungal bioactive natural products and assay development, the biosynthesis of secondary metabolites, as well as isolation and taxonomy of fungi.


Series Editor:

Paul M. Selzer studied biology, parasitology, and biochemistry at the University of T?bingen, Germany, where he also received his PhD in biochemistry. He spent three years at the Molecular Design Institute and the Parasitology and Tropical Disease Research Laboratory at the University of California, San Francisco. During his career he has worked as a researcher and scientific manager for several pharmaceutical companies, and is currently Head of Antiparasitics R&D at Boehringer Ingelheim Animal Health, Germany. He is also a visiting professor and teacher at the Biochemistry Institute of the University of T?bingen, and an honorary professor of the Department of Infection, Immunity, and Inflammation at the University of Glasgow, UK.

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The Guerrilla Factory: The Making of Special Forces Officers, the Green Berets

• Sales Rank: #11373365 in Books
• Published on: 2013
• Binding: Paperback

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• Sales Rank: #97243 in Books
• Brand: Random House
• Published on: 2015-06-16
• Released on: 2015-06-16
• Original language: English
• Number of items: 1
• Dimensions: 7.94" h x .63" w x 5.38" l,
• Binding: Hardcover
• 128 pages

Features

• A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's listing for full details.

About the Author
David Lewman has written more than sixty-five books starring SpongeBob SquarePants, Jimmy Neutron, the Fairly OddParents, G.I. Joe, the Wild Thornberrys, and other popular characters. He has also written scripts for many acclaimed television shows. David lives in Los Angeles with his wife, Donna, and their dog, Pirkle.

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By Jim Raynor
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Good read for younger readers
By Culz Paranormal
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By Eric Busse
I really felt like I had watched the movie after reading this book! It was excellent and I would recommend it to anyone who doesn't have a chance to see the film.

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In order to understand Tibetan religion, this thesis isolates the ritual of gcod (pronounced chöd) as a pillar of Tibetan cultural ingenuity for three main reasons. First, gcod developed during a critical period of cultural development in Tibet (tenth-thirteenth centuries); it epitomizes a renaissance formation of high culture. Second, studying gcod reveals the variety of soteriological, cosmological, and ritual influences that lead to a definitive Tibetan religion. Finally, the study of gcod yields important insights into the Tibetan religious economy that is the stage on which ritual and soteriological competition play out. While keeping these broader concerns in mind, gcod will be discussed in four chapters. In the first, the historical and cosmological contexts for gcod are discussed. In the second chapter, gcod’s fit into Buddhist soteriology will be described and affirmed. Third, the role of gcod in Tibetan local religion will be discussed along with descriptions of the gcod pa’s professional competitors. Finally, the gcod ritual proper will be described in as much detail as possible. In addition, both the introduction and the conclusion discuss possible avenues for gcod in ritual discourse (within religious studies). With these investigations in mind, this project will proceed to argue that the heart of all these innovations and syntheses is their this-worldly focus, which is generally true for Tibetan religion. The reason why gcod perpetuated is because it was instrumental in solving mundane problems, not because of the profundity of its doctrinal content.

• Sales Rank: #2163824 in eBooks
• Published on: 2010-03-06
• Released on: 2010-03-06
• Format: Kindle eBook

About the Author
Maxwell Irving studied Buddhism, shamanism, Tibetan history, Tibetan, and critical theory in Religious Studies while receiving his graduate degree at the University of Colorado at Boulder.

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4 of 4 people found the following review helpful.
Proper study on gCod
By SATO GOYU from Japan
Investigating significance of gCod (Chöd) tradition in the politico-religious history of Himalayan plateau from view point of cultural anthropology. Recommended for serious readers of "Civilized Shamans" of G.Samuel and "Machik's Complete Explanation" of S. Harding.

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Two sisters. One murder. And a woman who will cross the line to uncover a killer's secrets.
 
Though they are sisters, Kit and Jenny could not be more different. Jenny is the dutiful daughter, following in her father's footsteps to become a Texas cop. Now working as a detective in the Austin Police Department, Jenny is surprised when she sees a crime report with her sister's name on it.
 
Kit is the rebellious one, hiding from her past. She's trying to escape the fallout of her mother's death, and the gravitational pull of her father's expectations. Working as a stripper, Kit is living in a nighttime world of pseudonyms and lies. And she's begun to notice some new characters hanging around the club.
 
Suddenly, one sister's murder leads to the other's investigation of it, and brings her into a world more deadly than she can imagine. As the truth unfolds, one sister begins to question everything---even her own sanity---and the role she might have played in this lethal dance. The Devil's Backbone showcases Kim Wozencraft at her best: a novelist whose power to shock and compel you is unsurpassed.

• Sales Rank: #4437553 in Books
• Published on: 2006-09-05
• Released on: 2006-09-05
• Original language: English
• Number of items: 1
• Dimensions: 8.49" h x 1.23" w x 5.87" l,
• Binding: Hardcover
• 352 pages

From Publishers Weekly
Starred Review. In Wozencraft's brilliant third psychological thriller (after 2004's Wanted), Katherine "Kit" Metcalf must contend with post-traumatic stress (she was raped as a college student) and face her ultimate fear, her Texas Ranger dad, Wade, who hides immoral appetites behind a heroic image. A former realtor, Kit now pole dances for Blaze, "Austin's premier gentleman's club," though in order to do so she numbs herself with alcohol. Her sister, Jenny, an Austin police detective investigating a porn ring, is about to marry Luke Saner, an undercover cop looking into the murder of a Blaze regular. When Jenny's body later turns up in a Blanco County well, Kit seeks therapy and unwittingly puts her therapist (and herself) in danger. As the pace quickens, whom can she trust? Luke? Her dad? With eloquent prose that's unflinchingly honest, Wozencraft charts Kit's crusade for justice, revealing not only the rocky terrain of grief, addiction and rape recovery but also the smooth shores of survival. (Sept.)
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

Review
"The Devil's Backbone is a riveting study of psychological terror and ultimate betrayal, and a complex and compelling tale of a woman who journeys through the perilous territory of her own past to find answers to her sister's brutal murder. Kim Wozencraft's heroine is gritty, profane, and utterly compelling---you won't put this book down until the final shattering pages."
--Barbara Parker, author of Suspicion of Rage
"The Devil's Backbone is an experience: You live it as much as you read it, feeling in your own body every racing heartbeat and every degree of its merciless Texas heat. It is headlong, unremitting, and deeply passionate. Readers better make sure their seat belts are properly secured."
--Luc Sante, author of Low Life and Evidence."Wanted boasts impressively authentic detail. . . . Wozencraft's plainly spoken, richly populist style serves the material well, and the story moves faster than a speeding police car."
--Entertainment Weekly
"[Wozencraft] writes with equal authority and pathos about [the character's] opposing worlds…a deftly told jailbreak caper that provokes thought and goose bumps."
--People on Wanted
"Wozencraft writes with nervy brilliance…the novel switches from procedural to prison story to escape novel…without losing momentum. A chiller."
--Booklist on Wanted
"Fast and literate suspense…gripping all the way."
--Kirkus Reviews on Wanted
"For addicted crime-novel readers desperate for a fix, here's some methadone."
--San Francisco Chronicle on Wanted

From the Back Cover
From bestselling author Kim Wozencraft comes an "utterly compelling"* novel of shattering suspense about the ties that bind--and the evil that lurks in the hearts of men.
 
 "HARROWING."--ENTERTAINMENT WEEKLY
Though they are sisters, Kit and Jenny could not be more different. Jenny is the dutiful daughter, following in her father's footsteps to become a Texas cop. A detective in the Austin Police Department, she is surprised when she sees a crime report with her sister's name on it.
 
"POWERFUL."--BALTIMORE SUN
Rebellious Kit is always trying to escape the fallout of her mother's death and the gravitational pull of her father's expectations. Working as a stripper, she is living in a nighttime world of pseudonyms and lies. And she's begun to notice some new characters hanging around the club.
 
"UNREMITTING AND DEEPLY PASSIONATE."--LUC SANTE, author of Low LifeSuddenly, one sister's murder leads to the other's investigation of it, and brings her into a world more deadly than she can imagine. As the truth unfolds, one sister begins to question everything--even her own sanity--and the role she might have played in this lethal dance. *Barbara Parker

Most helpful customer reviews

1 of 1 people found the following review helpful.
tense psychological thriller
By A Customer
Katherine "Kit" Metcalf and her sister Jenny reacted differently to the family dynamics after their mom died. Whereas Jenny obeyed their martinet father by becoming a cop like him and is engaged to an undercover police officer, Kit chose philosophy in college and avoided anything remotely involving law enforcement. Adding to Kit's estrangement is a rape that she never has come to terms with or gotten over. In anger towards all males, Kit becomes a stripper at Austin's Blaze gentleman's club where she can safely tease men with glass between her and them.

However, the dynamics change again when Austin police detective Jenny, investigating a porn ring and related murder tied to Blaze, is found dead. Needing to obtain justice for the sister she feels she let down, Kit begins to obtain therapy with psychiatrist Dr. Emily Wolfe and investigates her sibling's murder over the objections of everyone she knows. However one objector has personal reasons to prevent Kit from succeeding either with therapy or her case. That adversary attacks Dr. Wolfe and steals Kit's file. Kit ponders if it is her dad, her late sister's fiancé Luke Saner, or someone else close to her who needs the truth to remain buried perhaps in her subconscious mind.

More a psychological thriller than an amateur sleuth tale, fans of both sub-genres and anyone who appreciates a deep character study will want to read this superb candid tale. The story line is action-packed, but it is the psyche of Kit that grips the audience as she grieves with no help from her stiff upper lip family who didn't help her when her mom died. Kim Wozencraft provides an incredible look at a woman over the edge without a safety net. The Devil's Backbone is a chillingly thrilling tale.

Harriet Klausner

3 of 3 people found the following review helpful.
Captivating characters, gripping plot
By N. Larrabee
Kit Metcalf wakes up in a park and does not remember how she got there. She's works as a dancer in a gentleman's club called Blaze's in Austin. Kit could not be more different than her sister Jenny. Jenny is a detective, engaged to be married soon. Kit meets Luke, Jenny's fiancé who has been working undercover at Blaze's. Kit was able to fend off an attacker in the club's parking lot. She could barely handle the news that her sister was murdered. Not knowing who to trust, she decides to counseling. Dr. Wolfe is soon threatened to stop seeing Kit and physically attacked. Another dancer from the club, Cheryl is found dead. She can't help but feel she's next. Kit needs to trust Luke as she tries to help him investigate Jenny's death. Complex, psychological thriller that is hard to put down.

0 of 0 people found the following review helpful.
Mediocre at best
By Sharksfan11
Cover calls it "A brilliant psychological thriller" I would definitely not go that far. I'm in a Mystery book club and this was the next book on the list. Story line is just Ok, I'd elaborate, but it seems the other reviewers have explained it enough. I guess if you are in the mood for a quick read it's ok, but there are better options.

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